There is a tool that Microsoft have developed that can apparently, make text that is displayed on your screen easier to read. It's only meant to work for LCD and Flat Panel screens, like laptops, so don't use it if you have a CRT monitor. It's called the ClearType Tuner, a font technology.
Use the ActiveX control: http://www.microsoft.com/typography/cleartype/tuner/Step1.aspx
Use the Powertoy: http://www.microsoft.com/typography/ClearTypePowerToy.mspx
Download the powertoy here, which allows you to access the settings from Control Panel.