Spoilers -
It's an ode to every key worker and anyone who has to relentlessly take care for others or strive for something important. People who spend so long working that they lose out on being a person: socialising, doing fun things, having a partner, even having a holiday and downtime. Spider Man just pushes through one emergency after another - and never feels the credit for it, and can't talk to anyone about it because he's keeping a secret (who he is). He's burnt out and suffering from long term stress.
His new arachnid powers are symbolic of flow state - having practised something so often that you your body autonomously takes over.
Him being immune to Jean Grey's mind control is not because of his Peter tingle or astral projection in No Way Home - it's because he's spent so long saving others and distanced himself from having friends that he's missing key parts of being human - connection, joy, rest.
I lost my mum to cancer like Peter. I was a key worker in lockdown and had to sacrifice friendship and partners and my physical and mental health for it - Peter had to give up his best friend and the live of his life so that he could keep being Spider Man, keep saving people. By the end he's all scratched up, physically and mentally.
